The role of O-GlcNAcylation in development
Ignacy Czajewski, Daan M. F. van Aalten
Abstract
O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis.
Topics & Concepts
BiologyMorphogenesisTransferaseCell biologyPosttranslational modificationEnzymeBiochemistryGeneGlycosylation and Glycoproteins ResearchGalectins and Cancer BiologyCarbohydrate Chemistry and Synthesis