CircRNA OXCT1 promotes the malignant progression and glutamine metabolism of non-small cell lung cancer by absorbing miR-516b-5p and upregulating SLC1A5
Hua Luo, Jianming Peng, Yuexi Yuan
Abstract
. Besides, miR-516b-5p was a target of circ-OXCT1, and miR-516b-5p inhibitor could relieve circ-OXCT1 absence-mediated effects in NSCLC cells. SLC1A5 was identified as a target of miR-516b-5p. Circ-OXCT1 promoted SLC1A5 expression by target binding with miR-516b-5p.Circ-OXCT1 facilitated NSCLC progression via miR-516b-5p-dependent regulation of SLC1A5, which provided a possible circRNA-targeted therapy for NSCLC.
Topics & Concepts
Gene knockdownCell growthFlow cytometryApoptosisCancer researchDownregulation and upregulationGene silencingmicroRNAMolecular biologyIn vivoChemistryCellWestern blotBiologyBiochemistryGeneBiotechnologyCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research