Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells
Andrea Petreni, Alessandro Bonardi, Carrie L. Lomelino, Sameh M. Osman, Zeid A. ALOthman, Wagdy M. Eldehna, Radwan El‐Haggar, Robert McKenna, Alessio Nocentini, Claudiu T. Supuran
Topics & Concepts
ChemistryCarbonic anhydraseStereochemistryCoumarinPyrimidineBiochemistryEnzymeOrganic chemistryEnzyme function and inhibitionSynthesis and Catalytic ReactionsSynthesis and Biological Evaluation