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Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells

Andrea Petreni, Alessandro Bonardi, Carrie L. Lomelino, Sameh M. Osman, Zeid A. ALOthman, Wagdy M. Eldehna, Radwan El‐Haggar, Robert McKenna, Alessio Nocentini, Claudiu T. Supuran

2020European Journal of Medicinal Chemistry70 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryCarbonic anhydraseStereochemistryCoumarinPyrimidineBiochemistryEnzymeOrganic chemistryEnzyme function and inhibitionSynthesis and Catalytic ReactionsSynthesis and Biological Evaluation
Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells | Litcius