Phosphocreatine attenuates doxorubicin-induced nephrotoxicity through inhibition of apoptosis, and restore mitochondrial function via activation of Nrf2 and PGC-1α pathways
Eskandar Qaed, Ahmed Al‐Maamari, Marwan Almoiliqy, Eman Alyafeai, Marwa Sultan, Waleed Aldahmash, Mueataz A. Mahyoub, Zeyao Tang
Topics & Concepts
NephrotoxicityPhosphocreatineDoxorubicinMitochondrionApoptosisBiologyNRF1PharmacologyGlutathioneMalondialdehydeKidneyOxidative stressCell biologyBiochemistryEndocrinologyChemotherapyEnzymeMitochondrial biogenesisGeneticsEnergy metabolismChemotherapy-induced cardiotoxicity and mitigationChemotherapy-induced organ toxicity mitigationElectron Spin Resonance Studies