Substitution of the chlorido ligand for PPh3 in anticancer organoruthenium complexes of sulfonamide-functionalized pyridine-2-carbothioamides leads to high cytotoxic activity
Shahid Iqbal, Waseeq Ahmad Siddiqui, Adnan Ashraf, Kelvin K. H. Tong, Farhana Aman, Tilo Söhnel, Stephen M. F. Jamieson, Muhammad Hanif, Christian G. Hartinger
Topics & Concepts
ChemistryCytotoxicityLigand (biochemistry)CisplatinPyridineSulfonamideStereochemistryCombinatorial chemistryIn vitroTriphenylphosphineIC50Medicinal chemistryReceptorBiochemistryChemotherapyCatalysisSurgeryMedicineMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsSynthesis and Biological Evaluation