TORC1 Determines Fab1 Lipid Kinase Function at Signaling Endosomes and Vacuoles
Zilei Chen, Pedro Carpio Malia, Riko Hatakeyama, Raffaele Nicastro, Zehan Hu, Marie-Pierre Péli-Gulli, Jieqiong Gao, Taki Nishimura, Elja Eskes, Christopher J. Stefan, Joris Winderickx, Jörn Dengjel, Claudio De Virgilio, Christian Ungermann
Abstract
. This, in turn, regulates (1) vacuole morphology, (2) recruitment of TORC1 and the TORC1-regulatory Rag GTPase-containing EGO complex to signaling endosomes, and (3) TORC1 activity. Thus, our study unravels a regulatory feedback loop between TORC1 and the Fab1 complex that controls signaling at endolysosomes.
Topics & Concepts
EndosomeCell biologyBiologyEndomembrane systemCrosstalkLysosomeBiogenesisVacuoleAutophagySignal transductionCytoplasmBiochemistryIntracellularGolgi apparatusEndoplasmic reticulumApoptosisOpticsPhysicsGeneEnzymeCellular transport and secretionCalcium signaling and nucleotide metabolismAutophagy in Disease and Therapy