Access to benzo[ <i>e</i> ][1,3]thiazin-4-ones <i>via</i> PCy <sub>3</sub> -mediated annulations of benzo[ <i>c</i> ][1,2]dithiol-3-ones with iso(thio)cyanates
Chengxiang Yi, Mao-Mei Zhu, Jie Ren, Weimin Zhu, Chuanjun Song, Yangang Wu
Abstract
A novel organophosphine-mediated annulation reaction of benzo[ c ][1,2]dithiol-3-ones with iso(thio)cyanates to synthesise benzo[ e ][1,3]thiazin-4-one derivatives has been developed, which proceeds via an S atom to C–N unit exchange strategy.
Topics & Concepts
ChemistryThio-DithiolMedicinal chemistryStereochemistryOrganic chemistrySynthesis of heterocyclic compoundsOrganic Chemistry Cycloaddition ReactionsSynthesis and Reactivity of Sulfur-Containing Compounds