African Swine Fever Virus Bearing an I226R Gene Deletion Elicits Robust Immunity in Pigs to African Swine Fever
Yanyan Zhang, Junnan Ke, Jingyuan Zhang, Jinjin Yang, Huixian Yue, Xintao Zhou, Yu Qi, Rongnian Zhu, Faming Miao, Qian Li, Fei Zhang, Ying Wang, Xun Han, Lijuan Mi, Jinmei Yang, Shoufeng Zhang, Teng Chen, Rongliang Hu
Abstract
of its virulent parental virus. Furthermore, the nucleic acid of the gene-deleted virus and its virulent parental virus was rarely detected from oral or anal swabs. Viruses could not be detected in any tissues after necropsy when viremia became negative, indicating that robust immunity was achieved. Therefore, SY18ΔI226R is a novel, ideal, and efficacious vaccine candidate for genotype II ASF.
Topics & Concepts
African swine fever virusViremiaBiologyVirologyViral sheddingAfrican swine feverOutbreakVirulenceImmunityVirusCullingAttenuated vaccineDNA vaccinationClassical swine feverImmunologyVaccinationAntibodyInactivated vaccineGeneDNA virusImmune systemTransmission (telecommunications)Intramuscular injectionHumoral immunityViral replicationSpecific-pathogen-freeDiseaseCellular immunityNovel virusVaccine efficacyImmunizationAnimal Disease Management and EpidemiologyMicrobial infections and disease researchVector-Borne Animal Diseases