Extracellular protein degradation via the lysosome
Mohamed A. Eldeeb, Cornelia E. Zorca, Thomas Goiran
Abstract
Tight regulation of protein levels is so crucial for cellular function that mammalian cells have evolved two parallel degradation systems. This article discusses how these systems can be exploited to selectively target proteins of interest for therapeutic purposes.
Topics & Concepts
LysosomeCell biologyExtracellularDegradation (telecommunications)Function (biology)Protein degradationChemistryComputational biologyBiologyComputer scienceBiochemistryEnzymeTelecommunicationsCellular transport and secretionAutophagy in Disease and TherapyCalcium signaling and nucleotide metabolism