Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming
Chenxiang Xi, Jiatong Sun, Xiaocui Xu, You Wu, Xiaochen Kou, Yanhong Zhao, Jiacheng Shen, Yu Dong, Kang Chen, Zhongqu Su, Dan Liu, Wen Ye, Yingdong Liu, Ran Zhang, Yiliang Xu, Hong Wang, Lujiang Hao, Li Wu, Shaorong Gao
Abstract
A-independent function of Mettl14 in reprogramming and provide new insight into the interplay between senescence and reprogramming in vitro.
Topics & Concepts
ReprogrammingKLF4BiologySomatic cellSOX2Induced pluripotent stem cellCell biologySenescencePhenotypeCancer researchCellGeneticsGeneEmbryonic stem cellRNA modifications and cancerEpigenetics and DNA MethylationCancer-related gene regulation