A brief guide to analyzing expression quantitative trait loci
Byung Su Ko, Sung Bae Lee, Tae-Kyung Kim
Abstract
Molecular quantitative trait locus (molQTL) mapping has emerged as an important approach for elucidating the functional consequences of genetic variants and unraveling the causal mechanisms underlying diseases or complex traits. However, the variety of analysis tools and sophisticated methodologies available for molQTL studies can be overwhelming for researchers with limited computational expertise. Here, we provide a brief guideline with a curated list of methods and software tools for analyzing expression quantitative trait loci, the most widely studied type of molQTL.
Topics & Concepts
Expression quantitative trait lociQuantitative trait locusComputational biologyExpression (computer science)BiologyGeneticsTraitEvolutionary biologyComputer scienceGenotypeGeneSingle-nucleotide polymorphismProgramming languageGenetic Mapping and Diversity in Plants and AnimalsGenetic and phenotypic traits in livestockGenetic Associations and Epidemiology