Iridium-Catalyzed C-Alkylation of Methyl Group on <i>N</i>-Heteroaromatic Compounds using Alcohols
Mitsuki Onoda, Ken‐ichi Fujita
Abstract
In this study, we developed a catalytic system for the C-alkylation of a methyl group on N-heteroaromatic compounds, including pyridine, pyrimidine, pyrazine, quinoline, quinoxaline, and isoquinoline, using alcohols based on a hydrogen-borrowing process with [Cp*IrCl2]2 (Cp*: η5-pentamethylcyclopentadienyl) combined with potassium t-butoxide and 18-crown-6-ether as the catalyst precursor.
Topics & Concepts
ChemistryAlkylationCatalysisIsoquinolinePyrazinePyridineIridiumQuinoxalineQuinolineMedicinal chemistryOrganic chemistryMethyl groupPyrimidinePotassiumGroup (periodic table)StereochemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisCatalytic C–H Functionalization Methods