Altered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque Infants
Katherine M. Bricker, Veronica Obregon-Perko, Brianna Williams, Danielle Oliver, Ferzan Uddin, Margaret Neja, Louis Hopkins, Amir Dashti, Sherrie Jean, Jennifer Wood, Stephanie Ehnert, Shan Liang, Thomas H. Vanderford, Gregory K. Tharp, Steven E. Bosinger, Amanda P. Schauer, Maud Mavigner, Mackenzie L. Cottrell, David M. Margolis, Richard M. Dunham, Ann Chahroudi
Abstract
While antiretroviral therapy (ART) has improved HIV-1 disease outcome and reduced transmission, interruption of ART results in rapid viral rebound due to the persistent latent reservoir. Interventions to reduce the viral reservoir are of critical importance, especially for children who must adhere to lifelong ART to prevent disease progression.
Topics & Concepts
BiologyViremiaDosingCmaxRhesus macaqueImmunologyPharmacokineticsImmune systemApoptosisMacaqueSimian immunodeficiency virusRegimenVirologyAndrologyPharmacologyVirusInternal medicineMedicinePaleontologyBiochemistryHIV Research and TreatmentHIV/AIDS drug development and treatmentImmune Cell Function and Interaction