The anticancer activity of an air-stable Pd(<scp>i</scp>)-NHC (NHC = N-heterocyclic carbene) dimer
Thomas Scattolin, Enrica Bortolamiol, Stefano Palazzolo, Isabella Caligiuri, Tiziana Perin, Vincenzo Canzonieri, Nicola Demitri, Flavio Rizzolio, Luigi Cavallo, Büşra Dereli, Manoj V. Mane, Steven P. Nolan, Fabiano Visentin
Abstract
A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.
Topics & Concepts
CarbeneDimerChemistryCancer cell linesStereochemistryMedicinal chemistryCombinatorial chemistryCancer cellCancerOrganic chemistryCatalysisBiologyGeneticsN-Heterocyclic Carbenes in Organic and Inorganic ChemistrySynthetic Organic Chemistry MethodsCatalytic Cross-Coupling Reactions