Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia
Juha Auvinen, Joona Tapio, Ville Karhunen, Johannes Kettunen, Raisa Serpi, Elitsa Y. Dimova, Dipender Gill, Pasi Soininen, Tuija Tammelin, Juha Mykkänen, Katri Puukka, Mika Kähönen, Emma Raitoharju, Terho Lehtimäki, Mika Ala‐Korpela, Olli T. Raitakari, Sirkka Keinänen‐Kiukaanniemi, Marjo‐Riitta Järvelin, Peppi Koivunen
Abstract
in skeletal muscle and adipose tissue, respectively, associated with systolic blood pressure in MR analyses and body weight, liver weight, and adiposity in mice. Last, manipulation of murine Hb levels mediated changes to key metabolic parameters. In conclusion, low-end normal Hb levels may be favorable for metabolic health involving mild chronic activation of the HIF response.
Topics & Concepts
Hypoxia (environmental)HemoglobinOxygen metabolismEnergy metabolismBiologyHypoxia-inducible factorsOxygenEndocrinologyChemistryBiochemistryGeneOrganic chemistryAdipose Tissue and MetabolismCancer, Hypoxia, and MetabolismHigh Altitude and Hypoxia