Therapeutic Strategies of Biologics in Chronic Rhinosinusitis: Current Options and Future Targets
Junhu Tai, Mun Soo Han, Tae Hoon Kim
Abstract
Chronic rhinosinusitis is a chronic inflammatory disease of the upper airways, for which treatment options include medical or surgical therapy. However, there are limitations to conservative treatment strategies, such as the relapse of nasal polyps. In this review, we discuss the rising role of biomolecular mechanisms associated with various biologics that have been approved or are undergoing clinical trials to treat chronic rhinosinusitis. We also highlight the potential molecular therapeutic targets for managing and treating chronic rhinosinusitis.
Topics & Concepts
Chronic rhinosinusitisMedicineIntensive care medicineNasal polypsDiseaseSinusitisClinical trialChronic diseaseMedical therapyImmunologyInternal medicineSinusitis and nasal conditionsAllergic Rhinitis and SensitizationAsthma and respiratory diseases