Modular Approaches to Lankacidin Antibiotics
Lingchao Cai, Yanmin Yao, Seul Ki Yeon, Ian B. Seiple
Abstract
-lankacidins to inhibit the growth of bacteria and to inhibit translation in vitro. This work grants insight into the rich chemical complexity of this class of antibiotics and provides an avenue for further structural derivatization.
Topics & Concepts
ChemistryPolyketideAntibioticsModular designClass (philosophy)Combinatorial chemistryStereochemistryProgramming languageOrganic chemistryArtificial intelligenceBiochemistryBiosynthesisComputer scienceEnzymeMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsSynthesis and Catalytic Reactions