Integrating oxygen-boosted sonodynamic therapy and ferroptosis <i>via</i> engineered exosomes for effective cancer treatment
Mingbo Wu, Zhanlin Zhang, Dong Li, Xiaomiao Ruan, Jingwen Yang, Siyi Chen, Xin Li, Wenwu Ling
Abstract
EXO@CAT combines endogenous proteins, which are prone to inactivation, with an exogenous sonosensitizer, allowing synergistic anticancer treatment of both ferroptosis and SDT with improved efficacy.
Topics & Concepts
Sonodynamic therapyMicrovesiclesCancer researchMedicineCancer therapyCancerPhotodynamic therapyCancer treatmentReactive oxygen speciesChemistrymicroRNAInternal medicineBiochemistryOrganic chemistryGeneNanoplatforms for cancer theranosticsExtracellular vesicles in diseasePhotoacoustic and Ultrasonic Imaging