Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells
Malte Lehmann, Kristina Allers, Claudia Heldt, Jenny Meinhardt, Franziska Schmidt, Yasmina Rodriguez‐Sillke, Désirée Kunkel, Michael Schümann, Chotima Böttcher, Christiane Stahl‐Hennig, Sefer Elezkurtaj, Christian Bojarski, Helena Radbruch, Victor M. Corman, Thomas Schneider, Christoph Loddenkemper, Verena Moos, Carl Weidinger, Anja A. Kühl, Britta Siegmund
Abstract
T cells are activated upon infection of intestinal epithelial cells with SARS-CoV-2, providing one possible explanation for gastrointestinal symptoms associated with COVID-19.
Topics & Concepts
Intraepithelial lymphocyteImmune systemGastrointestinal tractImmunologyImmunohistochemistryCD8BiologyIntestinal mucosaIntestinal epitheliumTropismSmall intestineEpitheliumPathologyMedicineVirusInternal medicineBiochemistrySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesImmune Cell Function and Interaction