Exercise-mitigated sex-based differences in aging: from genetic alterations to heart performance
Denise Börzsei, Dániel Priksz, Renáta Szabó, Mariann Bombicz, Zoltán Karácsonyi, László G. Puskás, Liliána Z. Fehér, Zsolt Radák, Krisztina Kupai, A. Berkó, Csaba Varga, Béla Juhász, Anikó Pósa
Abstract
Voluntary exercise has proved to be an effective therapeutic tool to improve cardiac function in aged rats with clearly visible sex differences. Long-term exercise is associated with decreased Ogn and Comt expression and enhanced presence of Pcp4 and Esm1 genes. Sex-dependent changes were also observed in the expression of the cardiovascular key proteins. Fundamental alterations in gene and protein expression may contribute to the improvement of cardiac performance.
Topics & Concepts
Cardiac function curveGene expressionMedicineProtein expressionInternal medicineGeneCardiologyBiologyBioinformaticsEndocrinologyHeart failureGeneticsCardiovascular Effects of ExerciseAdipose Tissue and MetabolismCardiomyopathy and Myosin Studies