2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling
Moataz A. Shaldam, Denisa Hendrychová, Radwan El‐Haggar, Veronika Vojáčková, Taghreed A. Majrashi, Eslam B. Elkaeed, Nicolas Masurier, Vladimı́r Kryštof, Haytham O. Tawfik, Wagdy M. Eldehna
Topics & Concepts
ChemistryHL60KinaseMyeloid leukemiaK562 cellsCell cultureLeukemiaBenzimidazoleIn vitroPharmacologyCancer researchBiochemistryBiologyImmunologyGeneticsOrganic chemistryQuinazolinone synthesis and applicationsSynthesis and biological activityCancer therapeutics and mechanisms