Glycyrrhiza uralensis polysaccharides ameliorates cecal ligation and puncture-induced sepsis by inhibiting the cGAS-STING signaling pathway
Siwen Hui, Wen Kan, Shuanglin Qin, Ping He, Zhao Jia, Hui Li, Bai Jun, Jincai Wen, Wenqing Mou, Manting Hou, Ziying Wei, Li Lin, Xiaohe Xiao, Guang Xu, Zhaofang Bai
Abstract
Graphical Abstract GUP can effectively inhibit the activation of cGAS-STING pathway induced by multiple stimuli and reduce the expression of type I interferon and pro-inflammatory cytokines. Meanwhile GUP also has a good therapeutic effect on sepsis contributed to cecum ligation and puncture.
Topics & Concepts
Glycyrrhiza uralensisStingCecumLigationPharmacologySepsisSignal transductionPolysaccharideMedicineInflammasomeChemistryInflammationImmunologyBiochemistryInternal medicinePathologyAerospace engineeringEngineeringAlternative medicineinterferon and immune responsesPharmacological Effects of Natural CompoundsInflammasome and immune disorders