Structural insight reveals SARS-CoV-2 ORF7a as an immunomodulating factor for human CD14+ monocytes
Ziliang Zhou, Chunliu Huang, Zhechong Zhou, Zhaoxia Huang, Lili Su, Sisi Kang, Xiaoxue Chen, Qiuyue Chen, Suhua He, Rong Xia, Fei Xiao, Jun Chen, Shoudeng Chen
Abstract
triggered a decrease in HLA-DR/DP/DQ expression levels and upregulated significant production of proinflammatory cytokines, including IL-6, IL-1β, IL-8, and TNF-α. Our work demonstrates that SARS-CoV-2 ORF7a is an immunomodulating factor for immune cell binding and triggers dramatic inflammatory responses, providing promising therapeutic drug targets for pandemic COVID-19.
Topics & Concepts
CD14Proinflammatory cytokineImmune systemImmunologyCoronavirusTumor necrosis factor alphaEctodomainBiologyInflammationVirologyMedicineCoronavirus disease 2019 (COVID-19)ReceptorInfectious disease (medical specialty)DiseaseBiochemistryPathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSARS-CoV-2 detection and testing