Dihydrotanshinone I Is Effective against Drug-Resistant Helicobacter pylori <i>In Vitro</i> and <i>In Vivo</i>
Peipei Luo, Yan-Qiang Huang, Xudong Hang, Qian Tong, Liping Zeng, Jia Jia, Guoxin Zhang, Hongkai Bi
Abstract
Helicobacter pylori is a major global pathogen and has been implicated in gastritis, peptic ulcer, and gastric carcinoma. The efficacy of the extensive therapy of H. pylori infection with antibiotics is compromised by the development of drug resistance and toxicity toward human gut microbiota, which urgently demands novel and selective antibacterial strategies.
Topics & Concepts
Helicobacter pyloriIn vivoAntibioticsPathogenGastritisDrug resistanceIn vitroPeptic ulcerDrugMicrobiologyAntibacterial agentPharmacologyHelicobacterMedicineBiologyInternal medicineBiotechnologyBiochemistryHelicobacter pylori-related gastroenterology studiesPhytochemical Studies and BioactivitiesPhytochemistry and Bioactive Compounds