Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Byung‐Chul Lee, Ashley Gin, Chuanfeng Wu, Komudi Singh, Max Grice, Ryland D. Mortlock, Diana M. Abraham, Xing Fan, Yifan Zhou, Aisha AlJanahi, Uimook Choi, Suk See De Ravin, Tae–Hoon Shin, Sogun Hong, Cynthia E. Dunbar
Topics & Concepts
CRISPRBiologyGenome editingRhesus macaqueHaematopoiesisStem cellTransduction (biophysics)Homing (biology)TransplantationViral vectorCell biologyCancer researchComputational biologyImmunologyGeneticsGeneMedicineInternal medicineRecombinant DNABiochemistryEcologyCRISPR and Genetic EngineeringVirus-based gene therapy researchCytomegalovirus and herpesvirus research