Polyhalogenation of Isoflavonoids by the Termite-Associated <i>Actinomadura</i> sp. RB99
Seoung Rak Lee, Felix Schalk, Jan W. Schwitalla, René Benndorf, John Vollmers, Anne‐Kristin Kaster, Z. Wilhelm de Beer, Minji Park, Mi‐Jeong Ahn, Won Hee Jung, Christine Beemelmanns, Ki Hyun Kim
Abstract
Based on high-resolution tandem mass spectrometry (HR-MS2) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.
Topics & Concepts
DaidzeinGenisteinIsoflavonesChemistryAntimicrobialBacteriaMass spectrometryFood scienceEnvironmental chemistryOrganic chemistryChromatographyBiologyBiochemistryEndocrinologyGeneticsInsect and Arachnid Ecology and BehaviorInsect and Pesticide ResearchPlant and animal studies