Direct C(<i>sp</i>)–H/Si–H Cross-Coupling via Copper Salts Photocatalysis
Qi‐Chao Gan, Ziqi Song, Chen‐Ho Tung, Li‐Zhu Wu
Abstract
)-H/Si-H cross-coupling by photocatalysis. In terms of cheap and readily available starting materials, a series of alkynylsilanes are prepared in good to excellent yields upon visible-light irradiation of CuCl and alkynes with silane. The large scale reaction with flow chemistry and late-stage functionalization of natural products shows the potential of the transformation in practical organic synthesis of the alkynylsilanes intermediates.
Topics & Concepts
ChemistryPhotocatalysisSilaneCopperSurface modificationCoupling reactionCoupling (piping)PhotochemistryCombinatorial chemistryOrganic chemistryCatalysisMetallurgyPhysical chemistryMaterials scienceRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques