Orally administered bismuth drug together with <i>N</i>-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy
Runming Wang, Jasper Fuk‐Woo Chan, Suyu Wang, Hongyan Li, Jiajia Zhao, Tiffany Ka-Yan Ip, Zhong Zuo, Kwok‐Yung Yuen, Shuofeng Yuan, Hongzhe Sun
Abstract
A cocktail therapy comprising bismuth drugs and N -acetyl- l -cysteine is reported to suppress the replication of SARS-CoV-2 via the oral route. The broad-spectrum inhibitory activities of the combination upon key viral cysteine enzymes are verified.
Topics & Concepts
DrugPharmacologyCoronavirus disease 2019 (COVID-19)CoronavirusBismuthBroad spectrumMedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PharmacotherapyVirologyChemistryInternal medicineCombinatorial chemistryDiseaseInfectious disease (medical specialty)Organic chemistrySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesViral Infections and Immunology Research