Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments
Mi Xiang, Yingdong Lu, Laiyun Xin, Jialiang Gao, Chang Shang, Zhilin Jiang, Hongchen Lin, Xuqin Fang, Yi Qu, Yuling Wang, Zihuan Shen, Mingjing Zhao, Xiangning Cui
Abstract
Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is currently the standard intervention. However, the reperfusion may lead to further myocardial damage, known as myocardial ischemia/reperfusion injury (MI/RI). Oxidative stress is one of the most important pathological mechanisms in reperfusion injury, which causes apoptosis, autophagy, inflammation, and some other damage in cardiomyocytes through multiple pathways, thus causing irreversible cardiomyocyte damage and cardiac dysfunction. This article reviews the pathological mechanisms of oxidative stress involved in reperfusion injury and the interventions for different pathways and targets, so as to form systematic treatments for oxidative stress-induced myocardial reperfusion injury and make up for the lack of monotherapy.