Cross-frequency phase-amplitude coupling in repetitive movements in patients with Parkinson’s disease
Ruxue Gong, Christoph Mühlberg, Mirko Wegscheider, Christopher Fricke, Jost‐Julian Rumpf, Thomas R. Knösche, Joseph Claßen
Abstract
Our findings using noninvasive EEG recordings provide evidence that PAC dynamics might play a role in the physiological cortical control of movement execution and may encode transitions between movement states. Results in patients with Parkinson's disease suggest that bradykinesia is related to a deficit of the dynamic regulation of PAC during movement execution rather than its absolute strength. Our findings may contribute to the development of a new concept of the pathophysiology of bradykinesia.
Topics & Concepts
NeuroscienceParkinson's diseaseMovement (music)PsychologyElectroencephalographyPhysical medicine and rehabilitationDiseaseMovement disordersMotor controlCoupling (piping)MedicinePhysicsMechanical engineeringPathologyEngineeringAcousticsEEG and Brain-Computer InterfacesNeural dynamics and brain functionNeurological disorders and treatments