Investigation of the Crosstalk between GRP78/PERK/ATF-4 Signaling Pathway and Renal Apoptosis Induced by Nephropathogenic Infectious Bronchitis Virus Infection
Wei Chen, Cheng Huang, Yan Shi, Ning Li, Enqi Wang, Ruiming Hu, Guyue Li, Fan Yang, Zhuang Yu, Ping Liu, Guoliang Hu, Xiaona Gao, Xiaoquan Guo
Abstract
Nephropathogenic infectious bronchitis virus (NIBV) induced renal endoplasmic reticulum stress in chickens. NIBV infection induced kidney apoptosis in chickens. GRP78/PERK/ATF-4 signaling pathway is potentially related to renal apoptosis induced by NIBV.
Topics & Concepts
BiologyApoptosisUnfolded protein responseEndoplasmic reticulumKidneyInfectious bronchitis virusCaspase 12Signal transductionWestern blotImmunologyVirologyMolecular biologyEndocrinologyVirusCell biologyCaspaseProgrammed cell deathGeneBiochemistryEndoplasmic Reticulum Stress and DiseaseViral gastroenteritis research and epidemiologyViral Infections and Vectors