A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin λ6 Light Chain Promotes Pathologic Amyloid Formation
Daniele Peterle, Elena S. Klimtchuk, Thomas E. Wales, Florian Georgescauld, Lawreen H. Connors, John R. Engen, Olga Gursky
Topics & Concepts
Point mutationAmyloidosisChemistryAmyloid (mycology)Immunoglobulin light chainContext (archaeology)BiophysicsHydrogen–deuterium exchangeAntigenMutationProteolysisBiochemistryAntibodyBiologyGeneticsMedicineInternal medicineEnzymeHydrogenOrganic chemistryPaleontologyGeneInorganic chemistryAmyloidosis: Diagnosis, Treatment, OutcomesMonoclonal and Polyclonal Antibodies ResearchDrug Transport and Resistance Mechanisms