Engineering Lipusu with lysophosphatidylcholine for improved tumor cellular uptake and anticancer efficacy
Lijie Li, Qi Zhan, Kaikai Yi, Ning Chen, Xueping Li, Shixue Yang, Xin Hou, Jin Zhao, Xubo Yuan, Chunsheng Kang
Abstract
inserting single chain lipid tails into liposomal lipid bilayers, which was realized by simple incubation. Compared with Lip, the better cellular uptake of liposomes modified with LPC resulted in enhanced cytotoxic activity of LPC-Lip in 4T1 cells. Furthermore, stronger tumor growth inhibition was observed in LPC-Lip treated 4T1 tumor-bearing mice without significant side effects. In conclusion, by modulating the lipid composition of Lip, the antitumor efficacy can be improved, and LPC engineered Lip may serve as a promising formulation of PTX for future cancer therapy.
Topics & Concepts
LysophosphatidylcholineTumor cellsCancer researchNanotechnologyMaterials scienceChemistryBiochemistryMedicinePhosphatidylcholinePhospholipidMembraneNanoparticle-Based Drug DeliveryLipid Membrane Structure and BehaviorSphingolipid Metabolism and Signaling