Gold nanoparticles conjugated with anti-CD133 monoclonal antibody and 5-fluorouracil chemotherapeutic agent as nanocarriers for cancer cell targeting
Manali Haniti Mohd-Zahid, Siti Nadiah Zulkifli, Che Azurahanim Che Abdullah, JitKang Lim, Sharida Fakurazi, Kah Keng Wong, Andee Dzulkarnaen Zakaria, Norzila Ismail, Vuk Uskoković, Rohimah Mohamud, Iskandar Z. A
Abstract
< 0.0001). This study shows that the conjugation of nanocarriers with the anti-CD133 antibody improves the specific targeting of 5-FU against colorectal cancer cells. These results demonstrate that simultaneous functionalisation of PEGylated AuNPs with antibodies and chemotherapeutic drugs is a viable strategy to combat cancer through targeted drug delivery.
Topics & Concepts
NanocarriersMonoclonal antibodyConjugated systemColloidal goldCancer researchChemistryMonoclonalCancer cellNanoparticlePharmacologyAntibodyCancerMedicineNanotechnologyDrugImmunologyInternal medicineMaterials scienceOrganic chemistryPolymerNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsGraphene and Nanomaterials Applications