Inhibition of esophageal-carcinoma cell proliferation by genistein via suppression of JAK1/2-STAT3 and AKT/MDM2/p53 signaling pathways
Jing Gao, Rongmu Xia, Jianbo Chen, Jing Gao, Xianyang Luo, Chunlin Ke, Caihong Ren, Jiayi Li, Yanjun Mi
Abstract
. Taken together, genistein suppressed the JAK1/2-STAT3 and AKT/MDM2/p53 signaling pathways by decreasing EGFR expression, leading to cell apoptosis, cell cycle arrest, and proliferation inhibition in EsC cells. Our findings suggest that genistein may be a promising alternative adjuvant therapy for patients with EsC.
Topics & Concepts
Protein kinase BCancer researchGenisteinMdm2STAT3ChemistryCell growthPhosphorylationSignal transductionCarcinomaInternal medicineMedicineApoptosisBiochemistryCancer-related Molecular PathwaysCytokine Signaling Pathways and InteractionsKruppel-like factors research