Distinct dual enzyme-like activities of Fe–N–C single-atom nanozymes enable discriminative detection of cellular glutathione
Chunqi Cai, Chengyang Zhu, Lingling Lv, Pengcheng Huang, Junjie Mao, Fang–Ying Wu, Ke‐Yu Deng
Abstract
Fe-N-C single-atom nanozymes readily achieved discriminative detection of glutathione (GSH) over other biothiols with similar structure due to the difference between POD-like and OXD-like activities regarding the kind of reactive oxygen species. This colorimetric sensor demonstrated the heterogeneity of GSH levels in different cells and accurately monitored cellular GSH fluctuation.
Topics & Concepts
Dual (grammatical number)ChemistryGlutathioneDiscriminative modelEnzymeAtom (system on chip)Combinatorial chemistryComputational biologyNanotechnologyComputer scienceBiochemistryMaterials scienceBiologyArtificial intelligenceEmbedded systemArtLiteratureAdvanced Nanomaterials in CatalysisNanocluster Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniques