Peak Work Rate Increases With Lower Extremity‐Focused Exercise Training in Adolescents With Fontan Circulation
Catherine M. Avitabile, Michael G. McBride, Xuemei Zhang, Steve Ampah, Bryan H. Goldstein, Tarek Alsaied, Samuel G. Wittekind, Kevin K. Whitehead, Babette S. Zemel, Stephen M. Paridon
Abstract
Background Skeletal muscle deficits are associated with worse exercise performance in the Fontan circulation and may be improved by exercise training. We aimed to assess the change in leg lean mass (a marker of skeletal muscle), exercise performance, and functional health status after a lower extremity‐focused exercise intervention in adolescents with Fontan circulation. Methods and Results Densitometry for measurement of leg lean mass, cardiopulmonary exercise test, exercise cardiac magnetic resonance, peripheral vascular testing, physical activity questionnaire, and quality of life assessment were performed at baseline and after a 24‐week, hybrid center‐ and home‐based training program. Leg lean mass Z‐scores were generated, and exercise parameters were expressed as percentage expected based on reference data. The effect of training was assessed by paired t‐tests and simple linear regression. Twenty participants (15.6±1.7 years, 50% male) demonstrated low baseline leg lean mass Z‐scores with no significant improvement with training (−1.38±1.02 pre versus −1.31±1.06 post, P =0.33). Maximum and percent predicted work increased from 121.9±29.8 (0.66±0.12) to 131.3±35.1 (0.70±0.15) watts ( P =0.02). Peak respiratory exchange ratio increased (1.19±0.02 versus 1.25±0.01, P =0.02) but percent predicted oxygen consumption was unchanged, suggesting higher anaerobic activity after training. Physical activity questionnaire score positively associated with peak work at baseline (ß=18.13 [95% CI, 0.83–35.44], R 2 =0.21; P =0.04) but physical activity questionnaire, quality of life scores, exercise cardiac magnetic resonance performance, and peripheral vascular function were unchanged with training. Conclusions Peak work rate and anaerobic activity increased with lower extremity‐focused training in adolescents with Fontan circulation. Larger studies should test the impact of these changes on functional status and quality of life.