Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70
Seung Yeob Hyun, Huong Thuy Le, Hye‐Young Min, Honglan Pei, Yijae Lim, Injae Song, Yen Nguyen, Suckchang Hong, Byung Woo Han, Ho‐Young Lee
Abstract
Our findings illustrate HSP70 as a potential target for eliminating CSCs and Evo as an effective HSP70-targeting anticancer drug eradicating both CSCs and non-CSCs with a minimal toxicity.
Topics & Concepts
Cancer stem cellCancer researchHomeobox protein NANOGBiologyStem cellHeat shock proteinCancer cellCell cultureChemistryCancerMolecular biologyCell biologyBiochemistryGeneticsInduced pluripotent stem cellGeneEmbryonic stem cellQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationCancer therapeutics and mechanisms