ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation
Na Cui, Chengyu Liu, Xiang Tang, Liangliang Song, Zixuan Xiao, Chen Wang, Yancai Wu, Yihao Zhou, Chentai Peng, Yuxia Liu, Ling Zheng, Xinran Liu, Kun Huang, Hong Chen
Abstract
ISG15 plays an important role in the development of AKI and subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation.
Topics & Concepts
ISG15Acute kidney injuryTransforming growth factorEpithelial–mesenchymal transitionKidneyTransition (genetics)MedicineCancer researchInternal medicineUrologyCell biologyChemistryBiologyGeneBiochemistryUbiquitinAcute Kidney Injury ResearchRenin-Angiotensin System StudiesS100 Proteins and Annexins