Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis
Loredana Moro, Daniele Simoneschi, Emma Kurz, Arnaldo Arbini, Shaowen Jang, Nicoletta Guaragnella, Sergio Giannattasio, Wei Wang, Yu‐An Chen, Geoffrey Pires, Andrew Dang, Elizabeth Hernández, Payal Kapur, Ankita Mishra, Aristotelis Tsirigos, George Miller, Jer‐Tsong Hsieh, Michele Pagano
Topics & Concepts
Ubiquitin ligaseCancer researchEpithelial–mesenchymal transitionMetastasisGene silencingBiologyMetastasis suppressorUbiquitinDNA methylationPancreatic cancerEpigeneticsCancerGene expressionGeneGeneticsBiochemistryUbiquitin and proteasome pathwaysCancer-related gene regulationHistone Deacetylase Inhibitors Research