Growth Hormone Overexpression Induces Hyperphagia and Intestinal Morphophysiological Adaptations to Improve Nutrient Uptake in Zebrafish
Marcela Gonçalves Meirelles, Bruna Félix da Silva Nornberg, Tony Silveira, Mateus Tavares Kütter, Caroline G. Castro, Juan Rafael B. Ramirez, Virgínia Fonseca Pedrosa, Luís Alberto Romano, Luís Fernando Marins
Abstract
Graphical Abstract GH overexpression increases the intestinal mass and absorptive surface area both through the direct effects of GH transgenics (up-regulating the expression of its cognate receptor and insulin-like growth factor, igf1a ) and through indirect effects through an increase in the amount of food consumed. In addition, hyperphagia provides a greater amount of nutrients in the intestinal lumen and stimulates the synthesis of di- and tri-peptide transporters, which are the main route of absorption of dietary products from protein degradation.