Anti-TNF-α Compounds as a Treatment for Depression
Sarit Uzzan, Abed N. Azab
Abstract
Millions of people around the world suffer from psychiatric illnesses, causing unbearable burden and immense distress to patients and their families. Accumulating evidence suggests that inflammation may contribute to the pathophysiology of psychiatric disorders such as major depression and bipolar disorder. Copious studies have consistently shown that patients with mood disorders have increased levels of plasma tumor necrosis factor (TNF)-α. Given these findings, selective anti-TNF-α compounds were tested as a potential therapeutic strategy for mood disorders. This mini-review summarizes the results of studies that examined the mood-modulating effects of anti-TNF-α drugs.
Topics & Concepts
Depression (economics)Mood disordersTumor necrosis factor alphaMoodBipolar disorderPsychiatryDistressMedicineMajor depressive disorderClinical psychologyPsychologyAnxietyInternal medicineMacroeconomicsEconomicsTryptophan and brain disordersBipolar Disorder and TreatmentStress Responses and Cortisol