Association of MRI Measures With Disease Severity and Progression in Progressive Supranuclear Palsy
Marina Picillo, Filomena Abate, Sara Ponticorvo, Maria Francesca Tepedino, Roberto Erro, Daniela Frosini, Eleonora Del Prete, Paolo Cecchi, Mirco Cosottini, Roberto Ceravolo, Gianfranco Di Salle, Francesco Di Salle, Fabrizio Esposito, Maria Teresa Pellecchia, Renzo Manara, Paolo Barone
Abstract
Irrespective of disease features and other MRI parameters, reduced midbrain size is significantly associated with greater ocular motor dysfunction at the time of MRI and more rapid disease progression over follow up. This is the first comprehensive study to systematically assess the association of available midbrain-based MRI measures and cortical volumes with disease severity and progression in a large cohort of patients with PSP in a real-world setting.
Topics & Concepts
Progressive supranuclear palsyMidbrainMedicineParkinsonismProportional hazards modelInternal medicineCardiologyDiseaseCentral nervous systemParkinson's Disease Mechanisms and TreatmentsAdvanced Neuroimaging Techniques and ApplicationsOphthalmology and Eye Disorders