Daidzein ameliorates doxorubicin-induced cardiac injury by inhibiting autophagy and apoptosis in rats
Jinxia Wu, Ke‐Xue Li, Yan Liu, Ailu Feng, Chunyang Liu, Joseph Adu‐Amankwaah, Miao‐Jin Ji, Yanhong Ma, Yanling Hao, Huimin Bu, Hong Sun
Abstract
: Daid reduced autophagy and apoptosis by inhibiting the PI3K/Akt pathway, thereby protecting the hearts from Dox-induced cardiac damage.
Topics & Concepts
CardiotoxicityDoxorubicinDaidzeinApoptosisProtein kinase BPharmacologyMedicineAutophagyChemistryEndocrinologyGenisteinInternal medicineToxicityChemotherapyBiochemistryChemotherapy-induced cardiotoxicity and mitigationCoenzyme Q10 studies and effectsElectron Spin Resonance Studies