Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin
Qian Cheng, Chunjie Yang, Mengting Lu, Jiaxin Bao, Haiyan Shen, Bingquan Deng, Shensen Li, Wenwen Li, Mu Zhang, Changchun Cao
Abstract
These results indicate a novel pathway for regulating NEP expression in neurons and that AhR may be a potential therapeutic target for the treatment of Alzheimer's disease.
Topics & Concepts
Aryl hydrocarbon receptorChromatin immunoprecipitationNeprilysinTranscription factorChemistryEndogenyMorris water navigation taskCell biologyInternal medicineBiologyEndocrinologyGene expressionBiochemistryEnzymeHippocampusPromoterMedicineGeneTryptophan and brain disordersAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research