Reagent free detection of SARS-CoV-2 using an antibody-based microwave sensor in a microfluidic platform
Weijia Cui, Pei Zhao, Jin Wang, Na Qin, Emmanuel A. Ho, Carolyn L. Ren
Abstract
for the SARS-CoV-2 antigen and 4000 copies per ml for the SARS-CoV-2 virus. The resonance frequency shift presents a linear relationship with the logarithm of antigen or virus concentration, respectively. This detection method is able to distinguish SARS-CoV-2 from the antigen of human CD4 and two human coronaviruses (MERS and HKU1), which presents a new pathway towards POC diagnosis of the COVID-19 at the community level. It presents the potential to detect other viruses by functionalizing the microwave sensor with respective antibodies.
Topics & Concepts
MicrofluidicsMicrowaveMicrochannelSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)AntigenVirusVirologyCoronavirus disease 2019 (COVID-19)NanotechnologyMaterials scienceComputer scienceBiologyMedicineImmunologyTelecommunicationsInfectious disease (medical specialty)DiseasePathologySARS-CoV-2 detection and testingRespiratory viral infections researchBiosensors and Analytical Detection