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Cardiomyocyte-localized CCDC25 senses NET DNA to promote doxorubicin cardiotoxicity by activating autophagic flux

Man Nie, Dexin Lei, Zhou Liu, Kuan Zeng, Xinyan Liang, Peng Huang, Yu Wang, Peng Sun, Hang Yang, Panpan Liu, Run‐Cong Nie, Silan Huang, Erwei Song, Wenqi Jiang, Zhiming Li, Yanqi Yang, Yi Xia, L Yang

2025Nature Cancer13 citationsDOI

Topics & Concepts

AutophagyCardiotoxicityDoxorubicinFlux (metallurgy)Cell biologyDNA damageDNAChemistryInternal medicineBiologyMedicineApoptosisToxicityBiochemistryChemotherapyOrganic chemistryChemotherapy-induced cardiotoxicity and mitigationATP Synthase and ATPases ResearchElectron Spin Resonance Studies
Cardiomyocyte-localized CCDC25 senses NET DNA to promote doxorubicin cardiotoxicity by activating autophagic flux | Litcius