Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction
Goutham Pattabiraman, Ashlee Bell-Cohn, Stephen F. Murphy, Daniel J. Mazur, Anthony J. Schaeffer, Praveen Thumbikat
Abstract
LUTS-associated benign prostatic hyperplasia is derived from a combination of immune activation, extracellular matrix remodeling, hyperplasia, and smooth muscle cell contraction in prostates of men. Using a mouse model, we describe the importance of mast cells in regulating these multiple facets involved in the pathophysiology of LUTS. Mast cell inhibition alleviates both pathology and urinary dysfunction in this model, suggesting the potential for mast cell inhibition as a therapeutic that prevents and reverses pathology and associated symptomology.
Topics & Concepts
Mast cellMedicineHyperplasiaFibrosisInflammationLower urinary tract symptomsProstateProstate cancerTryptaseBenign prostatic hyperplasia (BPH)Internal medicinePathologyImmunologyCancerUrinary Bladder and Prostate ResearchFood Allergy and Anaphylaxis ResearchSexual function and dysfunction studies