Synthesis, mechanisms of action, and toxicity of novel aminophosphonates derivatives conjugated irinotecan in vitro and in vivo as potent antitumor agents
Xiaochao Huang, Meng Wang, Qinghong You, Jing Kong, Haijiang Zhang, Chunhao Yu, Yanming Wang, Heng‐Shan Wang, Ri-Zhen Huang
Topics & Concepts
IrinotecanChemistryIn vivoPharmacologyCytotoxicityIn vitroMTT assayApoptosisMechanism of actionToxicityCancer cellCell cultureCell growthIC50CancerBiochemistryBiologyMedicineInternal medicineColorectal cancerOrganic chemistryGeneticsBiotechnologySynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activityOrganophosphorus compounds synthesis