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Chlorogenic acid can improve spermatogenic dysfunction in rats with varicocele by regulating mitochondrial homeostasis and inhibiting the activation of NLRP3 inflammasomes by oxidative mitochondrial DNA and cGAS/STING pathway

Zhichao Jia, Shengjing Liu, Tengfei Chen, Zhuozhuo Shi, Xiaolin Li, Zhaowang Gao, Qian Zhang, Chongfu Zhong

2024Bioorganic Chemistry17 citationsDOI

Topics & Concepts

Oxidative stressInflammationVaricoceleMitochondrionDNA damageEndocrinologyMale infertilityProinflammatory cytokineInternal medicineChemistryPharmacologyBiologyMedicineCell biologyInfertilityBiochemistryDNAPregnancyGeneticsinterferon and immune responsesInflammasome and immune disordersSperm and Testicular Function
Chlorogenic acid can improve spermatogenic dysfunction in rats with varicocele by regulating mitochondrial homeostasis and inhibiting the activation of NLRP3 inflammasomes by oxidative mitochondrial DNA and cGAS/STING pathway | Litcius